Celexa (Citalopram hydrobromide) was approved by the FDA in July 17, 1998.Celexa is manufactured by Forest Pharmaceuticals, Inc.Paxil probably has the most sedative effects among the SSRIs.Buspar may have a role in the augmentation of other medications, but has not been proven to be effective for treatment of panic disorder by itself.The goal in such development is to produce agents that are more efficacious, safer and better tolerated than older medications. Although all SSRI drugs have the same mechanism of action, each SSRI has slightly different pharmacological and pharmacokinetic characteristics.This leads to differences among the SSRIs in their half-lives, clinical activity, side effects, and drug interactions.Each type (class) of antidepressant affects these neurotransmitters in slightly different ways.
Side effects: Nausea, insomnia, headaches, sexual dysfunction, jitteriness, dry mouth, drowsiness.
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Other common side effects: headache, dry mouth, constipation, sweating, dizziness, sexual dysfunction.
Whom it may be suitable for: Depression sufferers with fatigue-like symptoms (norepinephrine works on the adrenal system); also a good option when SSRIs don’t work; not ideal for patients with hypertension.